Local Office Editing from the Web Client – Trust Center Approved hosts
When users open Office documents in Local office from the web client, users with new/updated versions of Microsoft Office installed locally may receive a warning about opening documents from online sources referencing the Trust Center.
It only applies to Local Office when opening from the Web Client. Clients opening in Local Office via the map drive, or Office 365 via the Web Client are unimpacted.
This is not an issue in the MyWorkDrive software; Microsoft introduced a change in Office to prompt for approval for 3rd party data sources starting in 2020, which has slowly been released to Office versions via updates. You can read more in detail here: